hydroquinone therapy
Click here for clinics where treatment is available
"Skin whitening agent" that suppresses melanin production

Hydroquinone is a topical preparation with strong bleaching properties.It suppresses the action of melanin, the pigment that causes age spots, and not only improves existing age spots, but is also effective in preventing future age spots.
Supervisor information

- 2010
- Graduated from Hiroshima University School of Medicine, Department of Medicine.
Worked at Saga Prefectural Hospital, Kyushu University Hospital, JCHO Kyushu Hospital, Fukuoka Red Cross Hospital, Kitakyushu Municipal Medical Center, Oita Prefectural Hospital, Kyushu Medical Center
- 2020
- Cosmetic dermatology Elm Clinic Fukuoka Clinic
- Japanese Society of Aesthetic Dermatology
- Juvederm Vista certified doctor
- Botox Vista certified doctor
- Cosmetic Ingredient Test Level 1
“What is hydroquinone?”
Hydroquinone is also called a ``skin whitening agent'' because it has a powerful whitening effect.It can be expected to suppress the action of melanin, the pigment that causes age spots, to reduce or eliminate age spots.In addition to improving existing stains, it is also effective in preventing future stains.
Effects and symptoms that can be improved with hydroquinone
Mechanism of action of hydroquinone
Hydroquinone is known to inhibit melanin production and has been used in dermatology for many years as an effective treatment for skin pigmentation. Melanin is the main element that determines skin color, and when produced in excess, it causes pigmentation such as age spots and freckles. Hydroquinone inhibits the activity of the enzyme tyrosinase, which plays an important role in the process of producing melanin, thereby suppressing melanin production and promoting improvement of existing pigmentation.
Effects that can be expected from hydroquinone
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stain reduction
Hydroquinone reduces dark spots by inhibiting melanin production and reducing existing melanin. Especially senile pigment spots(* 1), inflammatory pigmentation(* 2), melasma(* 3)Effective for stains such as.
*1. Stains that appear on the face and other areas due to the effects of UV rays over many years.
*2. Pigmentation that remains after acne and scars have healed.
*3. Irregularly shaped spots that appear mainly on the cheeks of women. -
Acne scars (redness) pigmentation
Hydroquinone also targets red and brown spots left behind by acne scars. The pigmentation that remains on your skin after acne has healed can also affect your appearance, making your skin look uneven. Hydroquinone contributes to improving these uneven tones and restoring the overall brightness of the skin.
It is recommended that hydroquinone be prescribed by a medical institution.
Proper concentration, use, and storage of hydroquinone are important.
In Japan, the ban on its use as a pharmaceutical was lifted in 2001, and since then it has been prescribed by many medical institutions. Correct treatment and UV protection are essential. Hydroquinone is also sensitive to light and heat, making it unsuitable for long-term storage. Therefore, it is recommended to keep it refrigerated and it is important to observe the expiration date.
Differences between over-the-counter products and prescription products at medical institutions
Currently, there are commercially available hydroquinone products that can be purchased from pharmacies such as drug stores and online shopping sites such as Amazon, but their concentrations are either lower than those prescribed by medical institutions or are uncertain. . If high concentrations of hydroquinone are used inappropriately, there is a risk of side effects such as inflammation and vitiligo. On the other hand, if the concentration is too low, you may not be able to achieve the desired effect.
Recommended for prescription in clinic
To avoid these risks and obtain the maximum effect of hydroquinone, it is recommended that it be prescribed by a medical institution. Consulting a specialist and receiving guidance on the appropriate concentration and usage method according to your skin condition and needs will lead to safe and effective use.
Function of hydroquinone
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Suppresses melanin production
It promotes skin turnover and removes dead skin cells.
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Improves stains from the root
Reduces the number of melanocytes (cells that produce melanin pigment).
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Improvement and prevention of stains
It improves existing stains and prevents future stains.
Side effects of hydroquinone
Hydroquinone is known to have a high whitening effect on pigmentation such as age spots and acne scars, but it is an ingredient that requires caution when used. Here, we will focus on two side effects that require special attention: ``skin redness/inflammation'' and ``vitiligo.''
Skin redness/inflammation
After using hydroquinone, your skin may feel red or irritated. This may be because hydroquinone is reacting and irritating sensitive areas of your skin. Redness and irritation are common immediately after starting use or when your skin is not used to hydroquinone.
approach
- Reduce the burden on your skin by reducing the amount or frequency of use.
- If you notice any redness or irritation on your skin, pause use and wait until your skin condition improves.
- If you experience strong irritation, it is important to stop using it immediately and consult a doctor.
White spot
Hydroquinone use may cause vitiligo to appear on the skin. This is a phenomenon where hydroquinone suppresses melanin production in the skin too much, causing areas of the skin to appear lighter than normal. Long-term use and high concentrations of hydroquinone are thought to increase this risk.
approach
- If vitiligo appears, it is important to immediately stop using hydroquinone and seek medical advice.
- As a preventive measure, when using hydroquinone, it is recommended to start with a low concentration and gradually get used to it while observing your skin's reaction.
How to use hydroquinone
What to prepare
- Hydroquinone
- At. TA Pure Skin Lotion
- Others (sunscreen/mask sheets)
Example of usage(Stain case)
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Face wash
When washing your face, wash gently with plenty of foam.Rubbing your skin too hard can cause pigmentation.
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At. Apply TA Pure Skin Lotion
Apply At. TA Pure Skin Lotion all over your face.We recommend using a commercially available mask sheet or a home iontophoresis device, as this will allow the product to penetrate the skin more easily.
-
apply hydroquinone
Apply hydroquinone to cover the stained area.Apply as thinly and widely as possible.The key is to apply it in a circular motion rather than rubbing it into your skin.After that, be sure to moisturize your skin thoroughly with the milky lotion or cream you normally use.
-
Always apply sunscreen in the morning
The skin in the area where hydroquinone is applied is more susceptible to UV rays than usual.Be sure to apply sunscreen (SPF 20 or higher, PA+ or higher) when going out.Don't forget to apply it indoors and in your car.
Treatment progress
- Redness and flakiness will appear about a week after the treatment.
- After a few more days, the skin around the reddened area will start to peel off.
- The redness of the skin will subside in about 2 to 3 weeks.
- Store hydroquinone in the refrigerator and use it within a month.After one month, the patient will come back to see the doctor, and after checking the condition of the patient's skin, we will prepare a new formulation and prescribe a new one.
*Hydroquinone is uniquely formulated at our hospital.As long-term storage is not effective, please be sure to use it within one month and discard it at home after that.
*<Side effects> Rarely, rash or skin irritation may occur.One in several people is allergic to hydroquinone and cannot use it.If you suspect redness, irritation, swelling, itching, allergic symptoms, pigmentation, color loss, dryness, etc., stop using the product immediately and consult a doctor.
HQ snow skin serum
- Hydroquinone
- whitening emulsion
11,000yen

An emulsion containing 4% hydroquinone.It is designed to avoid leaving a white cast when applied, and contains as few ingredients as possible that can induce allergies when used in combination with tretinoin.You can use it with confidence in a special container with a structure that prevents it from coming into contact with air.
Clinics where treatment is available
Residents of Kanto (Tokyo)
For those who live in the Chugoku region
For those who live in Kyushu
Hydroquinone price
External medicine
whitening agent
(tax included)Menu | Regular fee | Campaign fee | pack fee |
---|---|---|---|
Hydroquinone 5%(5g) [Fukuoka-in, Omotesando-in, Azabu-in] | 5,500JPY | - | - |
Click here for details on the fees for each treatment
About Payment Methods
You can choose the payment method that suits you.
Various combinations are possible.
- Lump sum cash
- Credit Transfer
- Medical loan(3 to 60 installments/annual interest rate 8.4%)
For minor patients
If you are a minor, a "parental consent form" is required.Please download and fill out the form in advance and bring it with you, or bring one of your parents with you.
Clinics where treatment is available
Residents of Kanto (Tokyo)
For those who live in the Chugoku region
For those who live in Kyushu

Hiroshi Kikuchi
- 2008
- Graduated from Hiroshima University School of Medicine, Department of Medicine Worked at Chiba University School of Medicine Affiliated Hospital and related hospitals.
- 2013
- Cosmetic dermatology Elm Clinic Fukuoka clinic opened
- Japanese Society of Aesthetic Dermatology
- Juvederm Vista certified doctor
- Botox Vista certified doctor
- Cosmetic Ingredient Test Level 1
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