Plureal
Densify series
Achieving “strong and beautiful skin from deep within”

The "Purreal Densifia Series" is a type of filler that increases moisture content deep within the skin, improving firmness, elasticity, and smoothness. It is a new Biostimulator formulation that enhances the skin's self-repairing ability and strengthens the skin's natural properties.
For those who are worried about the pain of the procedure
PN preparations (polynucleotides) such as Plurial, Rejuran, and Lizne are preparations that cause severe pain when injected. At Elm Clinic, we mix an anesthetic into the preparation using a unique formula to reduce the pain (an additional 3,300 JPY will be charged at the Osaka clinic if requested). By using a topical anesthetic in combination, the procedure can be performed with almost no pain.
Plurial Densify series is recommended for the following people
- Want to improve your skin's moisture, firmness, and elasticity?
- Concerned about fine lines around the eyes and mouth?
- I want to improve scars such as stretch marks and stretch marks.
- Want to improve dry skin such as atopic dermatitis?
Supervisor information
Yuichiro Uchiyama
- Graduated from Hiroshima University School of Medicine, Department of Medicine.
Works at a hospital in Tokyo
- Cosmetic Dermatology Elm Clinic Kyoto Clinic Works
- Juvederm Vista certified doctor
- Certified doctor trained in Allergan’s Vista program
What is “Plurial Densifier Series”?
"Plurial Densify series" is a bioremodeling preparation (biostimulation) specialized for skin regeneration. This is a filler series developed by MD Skin Solutions in Luxembourg, and is an injection agent (non-crosslinked hyaluronic acid) that has received CE approval.
By injecting this product, it is expected to increase the moisture content deep within the skin, improving firmness, elasticity, and skin texture. Furthermore, it is a new biostimulator formulation that promotes collagen production, enhances the skin's self-repair ability, and strengthens the skin's natural properties.

Features of “Plurial Densifier Series”
PLURYAL SILK
PLURYAL SILK is the world's first PN (polynucleotide) formulation to receive CE approval specifically for the eye area.
The product has been designed to be safer by increasing the purity of PN using a polynucleotide (PN) preparation and completely removing proteins, which greatly reduces the risk of allergies. It can be injected into areas with thin skin or delicate areas of the face, and is effective for repairing dark circles, fine lines, and scars. In addition, PN (polynucleotide) preparations have been reported to have a number of effects on skin regeneration, such as moisturizing the skin by producing collagen, promoting VEGF secretion, promoting angiogenesis, and antioxidant effects.
*As an initial treatment, 3 times every 3 weeks is recommended.

PLURYAL DENSIFY
PLURYAL DENSIFY is composed of a mixture of PN (polynucleotide), which has a skin repair effect, HA (non-crosslinked hyaluronic acid), which improves moisture and elasticity, and mannitol, which has an antioxidant effect and suppresses the decomposition of HA. It has been. It improves skin quality and makes the skin smoother, and has a proven track record of rejuvenating skin age overseas. Plurial Silk is suitable for injection into delicate areas such as around the eyes, while Plurial Densify is suitable for injection into the entire face, neck, décolletage, etc.
*As an initial treatment, 3 times every 3 weeks is recommended.

Features and benefits of Plureal Densifier series
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Point
Strengthen the skin's natural strength
Plureal Densify series is a type of filler that increases the moisture content deep inside the skin, gives skin firmness and elasticity, and improves skin quality. Unlike conventional fillers, it is a bioremodeling agent (biostimulation) that can promote collagen production, supplement the skin's natural self-repair function, and strengthen the skin's original structure.
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Point
skin age rejuvenation
The Plurial Densify series, which is attracting attention overseas, has many achievements in improving the overall skin texture, fine wrinkles, and firmness, and rejuvenating the skin's age. There are also experimental reports showing that those who received the injections had their skin rejuvenated by -15 years.
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Point
Safety
By completely removing proteins that tend to cause allergic reactions, the formulation has been designed to greatly reduce the risk of allergies and improve safety. Injection treatment is used by many people.
Treatment overview
| Duration of treatment | 60 to 90 minutes |
|---|---|
| pain | Depending on the area, you may experience a slight tingling pain or a dull pain during injection. |
| down time |
Immediately after injection, there will be some unevenness at the injection site, but in most cases it will disappear the next day or several days later. Internal bleeding may occur.Internal bleeding will gradually improve over about two weeks. |
| make | This is possible from the next day. |
| Points to note | Please refrain from using facial cleansing foam on the day of treatment. |
| Side effects | There are almost no side effects.In rare cases, redness, induration, swelling, or swelling may occur, but this will subside in about a week. |
| Treatment frequency | It is recommended that you undergo treatment approximately 3 times at intervals of XNUMX weeks, and then maintain treatment once every XNUMX months. |
*Pain, downtime, and effects vary from person to person.
*The treatment time does not include counseling time.
*Pregnant women cannot undergo any treatments.
Flow of treatment
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Flow of treatmentCounseling
Before the procedure, you will have a consultation with your doctor.During the consultation, you will receive a detailed explanation of the treatment area, effects, risks, costs, and aftercare.
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Flow of treatmentDisinfection/anesthesia
Disinfect before the treatment. If you wish, we will administer topical anesthesia (about 30 minutes).
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Flow of treatmentPlurial Densifer series injection
The doctor will inject Plureal Densify series. The amount and location of injection will be determined based on what was determined during the consultation.
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Flow of treatmentEnd of treatment
After the treatment, we will explain the aftercare.Please refrain from wearing makeup on the day of your appointment.
Pricing for the Plurial Densifier series
(tax included)| Menu | One-time fee | in the region |
|---|---|---|
| Purureal Silk (2cc) [Hiroshima Clinic, Okayama Clinic, Kumamoto Clinic, Osaka Clinic, Kobe Clinic, Azabu Clinic] | ¥49,800 (Addition of Botox costs an additional 10,000 JPY) |
3 times ¥130,000 |
| 1 Plurial Densify (2cc) | ¥59,800 (Addition of Botox costs an additional 10,000 JPY) |
3 times ¥160,000 |
| Purureal Densify (2 bottles) [Hiroshima, Fukuoka, Okayama, Kyoto, Kumamoto, Osaka, Kobe, Azabu Clinics] | ¥109,800 (Addition of Botox costs an additional 10,000 JPY) |
3 times ¥293,000 |
| Purureal Silk (1 bottle) + Densify (1 bottle) [Hiroshima Clinic, Okayama Clinic, Kumamoto Clinic, Osaka Clinic, Kobe Clinic, Azabu Clinic] | ¥99,800 (Addition of Botox costs an additional 10,000 JPY) |
3 times ¥279,000 |
| Surface anesthesia | ¥3,300 |
Click here for details on the fees for each treatment
About Payment Methods
You can choose the payment method that suits you.
Various combinations are possible.
- Lump sum cash
- Credit Transfer

- Medical loan(3 to 60 installments/annual interest rate 8.4%)
For minor patients
If you are a minor, a "parental consent form" is required.Please download and fill out the form in advance and bring it with you, or bring one of your parents with you.
FAQ
- How long does it take to see effects after injecting Plurial Densify series?
- If you perform the treatment once every three weeks, the third treatment is the standard.
- Can I go to work the next day?
- Internal bleeding may occur, but you can wear makeup the next day and hide it with concealer.
- Do you have any pain?
- Before the procedure, you will be given a topical anesthetic.Since this is an injection treatment, you may feel a slight pain depending on the location.
Clinics offering treatments with the Prureal Densiphia series
- Omotesando-in Temple
- Azabuin
- Kyotoin
- Osaka-in
- Kobein
- Hiroshima-in
- Okayamain
- Fukuoka-in
- Kumamoto-in
Elm Clinic Omotesando
- Address
- Zip code:107-0062
2F, 5-8-1 Minami-Aoyama, Minato-ku, Tokyo - Access
- 2-minute walk from Exit B1 of Omotesando Station on the Tokyo Metro.
- Medical time
- 9:30 ~ 18:30
[Regular closing day] Sunday *There may be temporary closures. - Phone Number
- 03-5962-6095
Elm Clinic Azabu
- Address
- Zip code:106-0045
4F, Azabu KF Building, 1-9-7 Azabu Juban, Minato-ku, Tokyo - Access
- 1-minute walk from Exit 5a of Azabu-Juban Station on the Tokyo Metro.
- Medical time
- Weekdays 10:00-19:00 / Saturdays, Sundays, and holidays 9:30-18:30
[Regular closing days] Irregular closing days *Temporary closures may also occur. - Phone Number
- 03-6807-4171
Elm Clinic Kyotoin
- Address
- Zip code:600-8031
594 Teianmae-cho, Teramachi-dori Shijo-sagaru, Shimogyo-ku, Kyoto City, Kyoto Prefecture, Okamoto Mirror Shop Building 4F - Access
- 3-minute walk from Exit 10 of Hankyu Railway's Kyoto Kawaramachi Station.
- Medical time
- 10:00 ~ 19:00
[Regular closing days] Irregular closing days *Temporary closures may also occur. - Phone Number
- 075-353-1854
Elm Clinic Osaka Clinic
- Address
- Zip code:530-0001
2F, Osaka Station Front Building No. 4, 1-11-4 Umeda, Kita-ku, Osaka City, Osaka Prefecture - Access
- 2-minute walk from Exit 8 of Higashi-Umeda Station on the Osaka Metro.
- Medical time
- 10:00 ~ 19:00
[Regular closing day] Sunday *There may be temporary closures. - Phone Number
- 06-6147-6761
Elm Clinic Kobe
- Address
- Zip code:650-0011
4F, Toei Building, 3-1-21 Shimoyamatedori, Chuo-ku, Kobe City, Hyogo Prefecture - Access
- 5-minute walk from the west exit of Hankyu Railway's Kobe Sannomiya Station.
- Medical time
- 9:00 ~ 18:00
[Regular closing days] Sundays and Mondays *There may be temporary closures. - Phone Number
- 078-335-6025
Elm Clinic Hiroshima
- Address
- Zip code:730-0051
5F Ueda Building, 1-4-14 Otemachi, Naka-ku, Hiroshima City, Hiroshima Prefecture - Access
- 3-minute walk from the Hondori tram stop on the Hiroshima Electric Railway.
- Medical time
- 9:00 ~ 18:00
[Regular closing day] Sunday *There may be temporary closures. - Phone Number
- 082-246-2406
Elm Clinic Okayama
- Address
- Zip code:700-0903
Actus Building B1F, 7-20 Saiwaicho, Kita-ku, Okayama City, Okayama Prefecture - Access
- 5-minute walk from JR Okayama Station, Korakuen Exit (East Exit)
- Medical time
- 9:00 ~ 18:00
[Regular closing day] Sunday *There may be temporary closures. - Phone Number
- 086-222-8772
Elm Clinic Fukuoka
- Address
- Zip code:810-0041
3F Center Building, 2-2-7 Daimyo, Chuo-ku, Fukuoka City, Fukuoka Prefecture - Access
- 4-minute walk from Exit 5 of Akasaka Station on the Fukuoka City Subway / 6-minute walk from Exit 2 of Tenjin Station on the Fukuoka City Subway
- Medical time
- 10:00 ~ 19:00
[Regular closing days] Irregular closing days *Temporary closures may also occur. - Phone Number
- 092-717-7227
Elm Clinic Kumamoto
- Address
- Zip code:860-0845
6-15 Kamitori-cho, Chuo-ku, Kumamoto City, Kumamoto Prefecture, Oaks Building 2, 3rd Floor - Access
- 5-minute walk from the Kumamoto City Tram "Toorimachi-suji" stop.
- Medical time
- 9:00 ~ 18:00
[Regular closing days] Irregular closing days *Temporary closures may also occur. - Phone Number
- 096-277-1950
Supervisor information (overall supervision, treatment supervision, column supervision)
Hiroshi Kikuchi
- 2008
- Graduated from Hiroshima University School of Medicine, Department of Medicine Worked at Chiba University School of Medicine Affiliated Hospital and related hospitals.
- 2013
- Cosmetic dermatology Elm Clinic Fukuoka clinic opened
- Juvederm Vista certified doctor
- Certified doctor trained in Allergan’s Vista program
- Cosmetic Ingredient Test Level 1
About medical advertising guidelines
At Elm Clinic, under the supervision of a doctor, we are reviewing and improving our website as appropriate in the following two areas, in accordance with the "Medical Advertising Guidelines."
(i) Addition/deletion of testimonials
(ii) When posting case photos, please describe the details of the treatment, risks of the treatment, price of the treatment, etc.
[Business hours] 9:00-18:00 [Closed] Sundays
*Temporary closures may be established.[Business hours] 10:00-19:00 [Closed days] Irregular holidays
*Temporary closures may be established.[Business hours] 9:00-18:00 [Closed] Sundays
*Temporary closures may be established.[Business hours] 10:00-19:00 [Closed days] Irregular holidays
*Temporary closures may be established.[Business hours] 9:00-18:00 [Closed days] Irregular holidays
*Temporary closures may be established.[Business hours] 10:00-19:00 [Closed] Sundays
*Temporary closures may be established.[Business Hours] 9: 00-18: 00
[Closed] Sundays and Mondays
[Business Hours] 9: 30-18: 30
[ Regular holiday ]Sunday
Weekdays 10:00-19:00 Saturdays, Sundays and holidays 9:30-18:30
[Regular holidays] Irregular holidays
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Hiroshima-in
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Fukuoka-in
@elmclinic.fukuoka View post -
Okayamain
@elmclinic_okayama View post -
Kyotoin
@elmclinic_kyoto View post -
Kumamoto-in
@elmclinic_kumamoto View post -
Osaka-in
@elmclinic.osaka View post -
Kobein
@elmclinic_kobe View post -
Omotesando-in Temple
@elmclinic_omotesando View post -
Azabuin
@elmclinic_azabu View post
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Director Kazuhito Aihara
@elm_kaz_ View post -
Hiroshima clinic doctor Madoka Hananoki
@dr.hananoki View post -
Director of Fukuoka Clinic Hiroshi Kikuchi
@dr_kikuchi View post -
Fukuokain doctor white water wings
@tsubasa_shirozu View post -
Fukuokain doctor Yusuke Hayakawa
@dr___yusuke View post -
Director of Kyoto Institute Yuichiro Uchiyama
@dr_yuichiro View post
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Director of Fukuoka Clinic Hiroshi Kikuchi
Director's blog View post -
Fukuokain doctor white water wings
Dr. Shiramizu's note View post -
Director of Okayama Clinic Tohru Takahashi
Director Tooru and staff blog View post










