Lituo
The 5th generation skin booster (skin nourishment injection) directly replenishes the foundation of your skin.

From conventional skin-nurturing injections that stimulate collagen production, we've shifted to "replenishing" and "reconstructing" by directly supplying the skin with its natural components.
Collagen, elastin, and hyaluronic acid are not only injected directly into depressions and nasolabial folds to fill them in, but you will also feel a firming sensation from within as time passes.
Furthermore, the ingredients penetrate deeply, creating a fresh, radiant glow and firmness from within the skin, leading to ideal skin through a double effect that slowly nurtures over time.
Re2O is recommended for people like this
- For those who want smoother, more radiant skin.
- For those who want to improve sagging pores or enlarged pores
- For those concerned about dryness and fine lines
- For those concerned about sunken cheeks, hollows, or nasolabial folds.
- For those who want to strengthen their skin itself
Supervisor information
Tsubasa Shirozu
- 2010
- Graduated from Hiroshima University School of Medicine, Department of Medicine.
Worked at Saga Prefectural Hospital, Kyushu University Hospital, JCHO Kyushu Hospital, Fukuoka Red Cross Hospital, Kitakyushu Municipal Medical Center, Oita Prefectural Hospital, Kyushu Medical Center
- 2020
- Cosmetic dermatology Elm Clinic Fukuoka Clinic
- Juvederm Vista certified doctor
- Certified doctor trained in Allergan’s Vista program
- Cosmetic Ingredient Test Level 1
What is "Re2O"?
Re2O is a fifth-generation skin booster (skin rejuvenation injection) whose main component is human cell-free dermal matrix (hADM).
Traditional skin-enhancing injections stimulated collagen production through skin stimulation (such as Jubeluk), or provided moisturizing and plumping effects with hyaluronic acid.
However, Re2O is a new skin booster that directly "replenishes" and "reconstructs" the foundation of the skin by injecting collagen, elastin, hyaluronic acid, etc. directly into the skin. It offers both immediate and long-lasting effects, promoting firmness, elasticity, and collagen production from within the skin, and gradually improving radiance, enlarged pores, and fine lines.
Developed by Humedix, it uses human-derived cell-free dermis (hADM) from FDA-approved facilities in the United States, thoroughly removing DNA and cellular components to minimize immune responses and allergy risks.

Features and Benefits of Re2O
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Point
Improvement of skin firmness and elasticity
By directly injecting deficient structural components, you can expect effects such as improved firmness, elasticity, and refined skin texture. A balanced composition within the skin results in a natural glow and transparency.
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Point
Improves sagging pores and enlarged pores
By plumping up the skin's foundation, you can also expect to see a tightening effect on sagging pores and enlarged pores that have been pulled down by gravity.
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Point
Also effective for sunken cheeks, hollows, and nasolabial folds.
Re2O can also be injected directly into wrinkles such as depressions and nasolabial folds. Unlike hyaluronic acid, it not only adds volume but also moisturizes and adds radiance to the skin, and over time, it gives a firming effect from within, resulting in a natural finish.
Treatment overview
| Duration of treatment | About 60 minutes |
|---|---|
| pain | Depending on the area, you may experience a slight tingling pain or a dull pain during injection. |
| down time |
Immediately after injection, there will be some unevenness at the injection site, but in most cases it will disappear the next day or several days later. Internal bleeding may occur.Internal bleeding will gradually improve over about two weeks. |
| make | This is possible from the next day. |
| Points to note | Please refrain from using facial cleansing foam on the day of treatment. |
| Side effects | Side effects are rare. In rare cases, swelling, redness, or bruising may occur, but these usually subside within about a week. |
| Treatment frequency | We recommend receiving 3 to 4 treatments at intervals of 2 to 4 weeks, and then maintaining the results with treatments once every six months. |
*Pain, downtime, and effects vary from person to person.
*The treatment time does not include counseling time.
*Pregnant women cannot undergo any treatments.
Flow of treatment
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Flow of treatmentCounseling
Before the procedure, you will have a consultation with your doctor.During the consultation, you will receive a detailed explanation of the treatment area, effects, risks, costs, and aftercare.
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Flow of treatmentDisinfection/anesthesia
Disinfect before the treatment. If you wish, we will administer topical anesthesia (about 30 minutes).
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Flow of treatmentRe2O injection
A doctor will inject Re2O. The amount and location of injection will be determined based on the consultation.
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Flow of treatmentEnd of treatment
After the treatment, we will explain the aftercare.Please refrain from wearing makeup on the day of your appointment.
Re2O pricing
(tax included)| Menu | One-time fee | in the region |
|---|---|---|
| 1 | ¥89,800 | 3 times ¥248,000 6 times ¥496,000 |
| Surface anesthesia | ¥3,300 |
Click here for details on the fees for each treatment
About Payment Methods
You can choose the payment method that suits you.
Various combinations are possible.
- Lump sum cash
- Credit Transfer

- Medical loan(3 to 60 installments/annual interest rate 8.4%)
For minor patients
If you are a minor, a "parental consent form" is required.Please download and fill out the form in advance and bring it with you, or bring one of your parents with you.
FAQ
- How long does it take for Re2O to show results?
- Since the treatment directly targets areas like depressions and nasolabial folds, you'll notice results immediately after the procedure. The product will settle into the skin within 1-2 weeks, giving it a moisturized and radiant appearance. After 1-2 months, the collagen and elastin will help reduce fine lines and tighten pores. However, continuing the treatment will allow you to experience even greater results.
- Can I go to work the next day?
- Internal bleeding may occur, but you can wear makeup the next day and hide it with concealer.
- Do you have any pain?
- If you are concerned about pain, we will apply topical anesthesia before the procedure. As this is an injection treatment, you may feel a slight stinging sensation depending on the location. Please feel free to let us know if you have any concerns.
Clinics offering Re2O treatments
- Osaka-in
Elm Clinic Osaka Clinic
- Address
- Zip code:530-0001
2F, Osaka Station Front Building No. 4, 1-11-4 Umeda, Kita-ku, Osaka City, Osaka Prefecture - Access
- 2-minute walk from Exit 8 of Higashi-Umeda Station on the Osaka Metro.
- Medical time
- 10:00 ~ 19:00
[Regular closing day] Sunday *There may be temporary closures. - Phone Number
- 06-6147-6761
Supervisor information (overall supervision, treatment supervision, column supervision)
Hiroshi Kikuchi
- 2008
- Graduated from Hiroshima University School of Medicine, Department of Medicine Worked at Chiba University School of Medicine Affiliated Hospital and related hospitals.
- 2013
- Cosmetic dermatology Elm Clinic Fukuoka clinic opened
- Juvederm Vista certified doctor
- Certified doctor trained in Allergan’s Vista program
- Cosmetic Ingredient Test Level 1
About medical advertising guidelines
At Elm Clinic, under the supervision of a doctor, we are reviewing and improving our website as appropriate in the following two areas, in accordance with the "Medical Advertising Guidelines."
(i) Addition/deletion of testimonials
(ii) When posting case photos, please describe the details of the treatment, risks of the treatment, price of the treatment, etc.
[Business hours] 9:00-18:00 [Closed] Sundays
*Temporary closures may be established.[Business hours] 10:00-19:00 [Closed days] Irregular holidays
*Temporary closures may be established.[Business hours] 9:00-18:00 [Closed] Sundays
*Temporary closures may be established.[Business hours] 10:00-19:00 [Closed days] Irregular holidays
*Temporary closures may be established.[Business hours] 9:00-18:00 [Closed days] Irregular holidays
*Temporary closures may be established.[Business hours] 10:00-19:00 [Closed] Sundays
*Temporary closures may be established.[Business Hours] 9: 00-18: 00
[Closed] Sundays and Mondays
[Business Hours] 9: 30-18: 30
[ Regular holiday ]Sunday
Weekdays 10:00-19:00 Saturdays, Sundays and holidays 9:30-18:30
[Regular holidays] Irregular holidays
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