Skin Plus
A high-purity ECM skin booster that nourishes from deep within the skin with its fine particles.

SkinPlus is a high-purity ECM skin booster that replicates the skin's natural structure based on human-derived ECM components.
By injecting components naturally present in the skin, this treatment has been clinically validated for improving skin texture, tone, elasticity, internal skin hydration, and skin density. It removes cellular components and nucleic acids (DNA and RNA) that could potentially trigger an immune response, making it a highly safe and effective skin-enhancing injection.
Skin Plus is recommended for people like this
- For those who want smoother, more radiant skin.
- For those who want to improve sagging pores or enlarged pores
- For those concerned about dryness and fine lines
- For those seeking natural rejuvenation
- For those who want to strengthen their skin's natural abilities
Supervisor information
Tsubasa Shirozu
- 2010
- Graduated from Hiroshima University School of Medicine, Department of Medicine.
Worked at Saga Prefectural Hospital, Kyushu University Hospital, JCHO Kyushu Hospital, Fukuoka Red Cross Hospital, Kitakyushu Municipal Medical Center, Oita Prefectural Hospital, Kyushu Medical Center
- 2020
- Cosmetic dermatology Elm Clinic Fukuoka Clinic
- Juvederm Vista certified doctor
- Certified doctor trained in Allergan’s Vista program
- Cosmetic Ingredient Test Level 1
What is "Skin Plus"?
SkinPlus is a high-purity ECM skin booster that replicates the skin's natural structure based on human-derived ECM components. Through a diverse range of components extracted from human skin tissue (a complex action of collagen, elastin, and GAGs) and a microparticle formulation (75 micrometers or less), its effects on skin texture, skin tone, elasticity, internal skin hydration, and skin density have been clinically proven.
Unlike conventional skin-enhancing injections that stimulate and promote skin cells, this is attracting attention as a fifth-generation skin booster that directly replenishes the components that the skin lacks.
Developed by Hans Biomed in South Korea, this product has received certification from the Korea Food and Drug Administration (MFDS), the Association of Banks and Trademarks (AATB), and the U.S. Food and Drug Administration (FDA), making it a highly safe formulation.

Skin Plus active ingredients
collagen
Collagen is an important protein that makes up about 70% of the dermis layer of the skin. It is effective in improving firmness, elasticity, sagging, and enlarged pores, giving the skin a feeling of being pushed back from within.
Elastin
It is an elastic protein that connects and supports collagen fibers together. It is effective in improving skin elasticity and preventing and reducing sagging and wrinkles.
GAGs (glycosaminoglycans)
It possesses extremely high water retention capacity, holding a large amount of moisture within the dermis. It prevents dryness, maintains fresh and moisturized skin, and promotes support and repair of the skin's barrier function.
Comparison of SkinPlus and Juvellook
| Formulation name | Skin Plus | juve look |
|---|---|---|
| Principal component | Human-derived ECM (collagen, elastin, GAGs) | PLLA (Polylactic Acid: Collagen Stimulation) |
| Specialty | Natural skin texture improvement and overall enhancement | Improvement of pores, uneven texture, and acne scars |
| pain | Few | Somewhat |
| Immediate effect | I felt the effects the very next day. | The effects will gradually become apparent after 1-2 weeks. |
| Suitable problems | Pores, firmness, texture, dryness | Enlarged pores, acne scars, uneven skin texture |
| downtime | Less | Somewhat likely to occur (redness, wheals, etc.) |
SkinPlus case photos


- Our Treatments
Skin Plus 1 session
- Treatment amount
- 89,800 JPY(TAX+)
- Side effects
- Redness, swelling, pain, bruising, temporary bumps, itching
- Doctor in charge
- Tsubasa Shirozu
SkinPlus Features and Benefits
-
Point
Fine particles allow for easy penetration.
It is processed into microparticles smaller than 75 μm, which naturally spread and are absorbed within the skin tissue.
-
Point
You can feel the effects relatively quickly.
Because it directly replenishes skin's structural components such as collagen and elastin, it's easy to notice a change in firmness and radiance.
-
Point
It prepares the skin's foundation and provides multiple skin texture improvement effects.
Skin Plus directly replenishes the components that your skin lacks, and is expected to improve the quality of your skin from the foundation up. It addresses multiple concerns that increase with age, such as fine lines caused by dryness, enlarged pores, and loss of firmness and radiance.
Treatment overview
| Duration of treatment | About 30 minutes |
|---|---|
| pain | Depending on the area, you may experience a slight tingling pain or a dull pain during injection. |
| down time |
Immediately after injection, there will be some unevenness at the injection site, but in most cases it will disappear the next day or several days later. Internal bleeding may occur.Internal bleeding will gradually improve over about two weeks. |
| make | This is possible from the next day. |
| Points to note | Please refrain from using facial cleansing foam on the day of treatment. |
| Side effects | Side effects are rare. In rare cases, swelling, redness, or bruising may occur, but these usually subside within about a week. |
| Treatment frequency | We recommend receiving treatments 3-4 times a month, followed by maintenance treatments every six months. |
*Pain, downtime, and effects vary from person to person.
*The treatment time does not include counseling time.
*Pregnant women cannot undergo any treatments.
Flow of treatment
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Flow of treatmentCounseling
Before the procedure, you will have a consultation with your doctor.During the consultation, you will receive a detailed explanation of the treatment area, effects, risks, costs, and aftercare.
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Flow of treatmentDisinfection/anesthesia
Disinfect before the treatment. If you wish, we will administer topical anesthesia (about 30 minutes).
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Flow of treatmentSkin Plus injection
A doctor will inject SkinPlus. The amount and location of injection will be determined based on the information gathered during the consultation.
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Flow of treatmentEnd of treatment
After the treatment, we will explain the aftercare.Please refrain from wearing makeup on the day of your appointment.
Skin Plus pricing
(tax included)| Menu | Regular fee | in the region |
|---|---|---|
| 1 | ¥89,800 | 3 times ¥248,000 6 times ¥496,000 |
| Surface anesthesia | ¥3,300 |
Click here for details on the fees for each treatment
About Payment Methods
You can choose the payment method that suits you.
Various combinations are possible.
- Lump sum cash
- Credit Transfer

- Medical loan(3 to 60 installments/annual interest rate 8.4%)
For minor patients
If you are a minor, a "parental consent form" is required.Please download and fill out the form in advance and bring it with you, or bring one of your parents with you.
FAQ
- How long does it take to see results from SkinPlus?
- Since the treatment directly targets areas like depressions and nasolabial folds, you'll notice results immediately after the procedure. The product will settle into the skin within 1-2 weeks, giving it a moisturized and radiant appearance. After 1-2 months, the collagen and elastin will help reduce fine lines and tighten pores. However, continuing the treatment will allow you to experience even greater results.
- Can I go to work the next day?
- Internal bleeding may occur, but you can wear makeup the next day and hide it with concealer.
- Do you have any pain?
- If you are concerned about pain, we will apply topical anesthesia before the procedure. As this is an injection treatment, you may feel a slight stinging sensation depending on the location. Please feel free to let us know if you have any concerns.
Clinics offering Skin Plus treatments
- Osaka-in
- Okayamain
- Fukuoka-in
Elm Clinic Osaka Clinic
- Address
- Zip code:530-0001
2F, Osaka Station Front Building No. 4, 1-11-4 Umeda, Kita-ku, Osaka City, Osaka Prefecture - Access
- 2-minute walk from Exit 8 of Higashi-Umeda Station on the Osaka Metro.
- Medical time
- 10:00 ~ 19:00
[Regular closing day] Sunday *There may be temporary closures. - Phone Number
- 06-6147-6761
Elm Clinic Okayama
- Address
- Zip code:700-0903
Actus Building B1F, 7-20 Saiwaicho, Kita-ku, Okayama City, Okayama Prefecture - Access
- 5-minute walk from JR Okayama Station, Korakuen Exit (East Exit)
- Medical time
- 9:00 ~ 18:00
[Regular closing day] Sunday *There may be temporary closures. - Phone Number
- 086-222-8772
Elm Clinic Fukuoka
- Address
- Zip code:810-0041
3F Center Building, 2-2-7 Daimyo, Chuo-ku, Fukuoka City, Fukuoka Prefecture - Access
- 4-minute walk from Exit 5 of Akasaka Station on the Fukuoka City Subway / 6-minute walk from Exit 2 of Tenjin Station on the Fukuoka City Subway
- Medical time
- 10:00 ~ 19:00
[Regular closing days] Irregular closing days *Temporary closures may also occur. - Phone Number
- 092-717-7227
Supervisor information (overall supervision, treatment supervision, column supervision)
Hiroshi Kikuchi
- 2008
- Graduated from Hiroshima University School of Medicine, Department of Medicine Worked at Chiba University School of Medicine Affiliated Hospital and related hospitals.
- 2013
- Cosmetic dermatology Elm Clinic Fukuoka clinic opened
- Juvederm Vista certified doctor
- Certified doctor trained in Allergan’s Vista program
- Cosmetic Ingredient Test Level 1
About medical advertising guidelines
At Elm Clinic, under the supervision of a doctor, we are reviewing and improving our website as appropriate in the following two areas, in accordance with the "Medical Advertising Guidelines."
(i) Addition/deletion of testimonials
(ii) When posting case photos, please describe the details of the treatment, risks of the treatment, price of the treatment, etc.
[Business hours] 9:00-18:00 [Closed] Sundays
*Temporary closures may be established.[Business hours] 10:00-19:00 [Closed days] Irregular holidays
*Temporary closures may be established.[Business hours] 9:00-18:00 [Closed] Sundays
*Temporary closures may be established.[Business hours] 10:00-19:00 [Closed days] Irregular holidays
*Temporary closures may be established.[Business hours] 9:00-18:00 [Closed days] Irregular holidays
*Temporary closures may be established.[Business hours] 10:00-19:00 [Closed] Sundays
*Temporary closures may be established.[Business Hours] 9: 00-18: 00
[Closed] Sundays and Mondays
[Business Hours] 9: 30-18: 30
[ Regular holiday ]Sunday
Weekdays 10:00-19:00 Saturdays, Sundays and holidays 9:30-18:30
[Regular holidays] Irregular holidays
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Director of Fukuoka Clinic Hiroshi Kikuchi
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Director of Okayama Clinic Tohru Takahashi
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